John lazar obituary palo alto
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Published in sista edited struktur as: Cell. 2018 Apr 5;173(2):338–354.e15. doi: 10.1016/j.cell.2018.03.034
SUMMARY
Cancer progression involves the gradual loss of a differentiated phenotype and acquisition of progenitor and stem cell-like features. Here, we provide novel stemness indices for assessing the grad of oncogenic dedifferentiation. We used an innovative one-class logistic regression machine learning algorithm (OCLR) to extrakt transcriptomic and epigenetic feature sets derived from non-transformed pluripotent stem cells and their differentiated progeny. Using OCLR, we were able to identify previously undiscovered biological mechanisms associated with the dedifferentiated oncogenic state. Analyses of the tumor microenvironment revealed unanticipated correlation of cancer stemness with immune checkpoint expression and infiltrating immune system cells. We funnen that the dedifferentiated oncogenic phenotype was generally m
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Joel Neal, MD, PhD
Professor of Medicine (Oncology)
Medicine - Oncology
Practices at Stanford Health Care
Bio
Dr. Neal holds a medical degree and a doctoral degree in Tumor Cell Biology from Northwestern University in Chicago, Illinois. Subsequently, he completed a fellowship in oncology, rotating through the Dana-Farber Cancer Institute and Massachusetts General Hospital in Boston, Massachusetts. He is currently a Professor in the Division of Oncology at the Stanford Cancer Institute at Stanford University in Palo Alto, California. Dr Neal’s primary clinical interest is in thoracic oncology. In addition to maintaining an active practice, he focuses on the design and conduct of clinical trials involving targeted therapies and immunotherapy for lung cancer and mesothelioma. He has published dozens of articles in the field of thoracic oncology, including in Lancet Oncology, Nature Medicine, and the Journal of Clinical Oncology. He is a member of the International Assoc
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John Lazar OBITUARY
John Arthur Lazar September 24, 1933 – April 25, 2013 Resident of Woodside With his family at his side, loving husband, dear father, cherished friend, mentor and community leader died peacefully on Thursday, April 25th. John graduated from University of California in 1956 and received his MBA from Stanford in 1958. He began his life long career in real estate at Hare Brewer and Kelley. Over the course of his distinguished career, he joined a broker partnership at California Lands Investment Company, served as manager and partner at Cornish & Carey Realtors, and Manager for both Coldwell Banker and Cashin Company. John was always politically liberal: In 1964 when Proposition 14 (sponsored by the California Real Estate Association and endorsed by the Republican Assembly) briefly overturned the Rumsford Fair Housing Act, John openly opposed it and became an ardent supporter and member of the newly formed Mid-Peninsula Citizens for Fair Housing